iPS Cells Department


The Discoveries of Yamanaka Factors Section


In this department,studying about the discoveries of Yamanaka factors will be carried out.

Dr.Yamanaka's researching started from pinpointing proteins which is necessary to initialize cells (to return such the state as fertilized eggs) as you have studied in the research department of Dr.Yamanaka.

However,he did not know even how many protein is necessary to format it in those days.

Then,he made a list of one hundred proteins which work actively in ES cells,and he decided to look for in the list.

It took no less than four years to narrow down protein which is necessary from 100 to 24.

The following pictures is the process that he narrowed down vital protein to initialize from 24 to 4.

①No at least one piece happens initialization


②Initialization happens if 24 all




③Which genes is really necessary?






④Succeeded in narrowing 4 vital protein


You understood what Yamanaka factors is,didn't you?

Then,let's go to the next department!


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