Antibody drugs are being researched all over the world, and some of them have been approved. Let’s take a look at the mechanism of antibody drugs that have been approved in the field of oncology, which is a major target of antibody drugs!
A typical antibody drug is a breast cancer drug that utilizes "HER2". In addition, it is also possible to use it to treat other types of cancer such as breast cancer.
Antibodies can inhibit the growth of cancer by binding to HER2. In addition, it can also enhance the function of killer cells and macrophages that directly attack cancer. This is the first antibody drug approved for the treatment of solid tumors, and is one of the pioneering drugs in this field.
Have you ever heard of OPVIBO? This is the brand name of an immune checkpoint inhibitor called "Nivolumab", for which special professor Tasuku Honjo of Kyoto University was awarded the Nobel Prize for his discovery. Cancer cells have a mechanism to stop the attack of T cells that attack the cancer. The "PD-L1" of the cancer cells binds to the "PD-1" of the T cells, thereby putting the brakes on the T cell attack.
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